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Statistical Monitoring Of Clinical Trials A Unified Approach 2007 Edition at Meripustak

Statistical Monitoring Of Clinical Trials A Unified Approach 2007 Edition

Books from same Author: Michael A. Proschan K. K. Gordon Lan Janet Turk Wittes

Books from same Publisher: Springer

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    • General Information  
    Author(s)Michael A. Proschan K. K. Gordon Lan Janet Turk Wittes
    PublisherSpringer
    ISBN9780387300597
    Pages268
    BindingHardback
    LanguageEnglish
    Publish YearDecember 2007

    Description

    Springer Statistical Monitoring Of Clinical Trials A Unified Approach 2007 Edition by Michael A. Proschan K. K. Gordon Lan Janet Turk Wittes

    The approach taken in this book is to studies monitored over time what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the B-value") - irrespective of the test statistic. Thus this book offers statisticians an accessible incremental approach to understanding Brownian motion as related to clinical trials. Table of contents : A General Framework.- Power: Conditional Unconditional and Predictive.- Historical Monitoring Boundaries.- Spending Functions.- Practical Survival Monitoring.- Inference Following a Group-Sequential Trial.- Options When Brownian Motion Does Not Hold.- Monitoring for Safety.- Bayesian Monitoring.- Adaptive Sample Size Methods.- Topics Not Covered.- Appendix I: The Logrank and Related Tests.- Appendix II: Group-Sequential Software.