Description
Wiley India Voets Biochemistry Adapted Edition 2021 Edition by VOET D.
The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. It incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. Table of Contents Guide to Media Resources Part I Introduction and BackgroundChapter 1 Life1. Prokaryotes2. Eukaryotes3. Biochemistry: A Prologue4. Genetics: A Review5. The Origin of Life6. The Biochemical Literature Chapter 2 Aqueous Solutions1. Properties of Water2. Acids, Bases, and Buffers Chapter 3 Thermodynamic Principles: A Review1. First Law of Thermodynamics: Energy Is Conserved2. Second Law of Thermodynamics: The Universe Tends Toward Maximum Disorder3. Free Energy: The Indicator of Spontaneity4. Chemical EquilibriaAppendix: Concentration Dependence of Free Energy Part II BiomoleculesChapter 4 Amino Acids1. The Amino Acids of Proteins2. Optical Activity3. “Nonstandard” Amino Acids Chapter 5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology1. Nucleotides and Nucleic Acids2. DNA Is the Carrier of Genetic Information3. Double Helical DNA4. Gene Expression and Replication: An Overview5. Molecular Cloning Chapter 6 Techniques of Protein and Nucleic Acid Purifications1. Protein Isolation2. Solubilities of Proteins3. Chromatographic Separations4. Electrophoresis5. Ultracentrifugation6. Nucleic Acid Fractionation Chapter 7 Covalent Structures of Proteins and Nucleic Acids1. Primary Structure Determination of Proteins2. Nucleic Acid Sequencing3. Chemical Evolution4. Bioinformatics: An Introduction5. Chemical Synthesis of Polypeptides6. Chemical Synthesis of Oligonucleotides Chapter 8 Three-Dimensional Structures of Proteins1. Secondary Structure2. Fibrous Proteins3. Globular Proteins4. Protein Stability5. Quaternary StructureAppendix: Viewing Stereo Pictures Chapter 9 Protein Folding, Dynamics, and Structural Evolution1. Protein Folding: Theory and Experiment2. Folding Accessory Proteins3. Protein Structure Prediction and Design4. Protein Dynamics5. Conformational Diseases: Amyloids and Prions6. Structural Evolution Chapter 10 Hemoglobin: Protein Function in Microcosm1. Hemoglobin and Myoglobin Function2. Structure and Mechanism3. Abnormal Hemoglobins4. Allosteric RegulationAppendix: Derivation of Symmetry Model Equations Chapter 11 Sugars and Polysaccharides1. Monosaccharides2. Polysaccharides3. Glycoproteins Chapter 12 Lipids and Membranes1. Lipid Classification2. Properties of Lipid Aggregates3. Biological Membranes4. Membrane Assembly and Protein Targeting5. Lipoproteins Part III Mechanisms of Enzyme ActionChapter 13 Introduction to Enzymes1. Historical Perspective2. Substrate Specificity3. Coenzymes4. Regulation of Enzymatic Activity5. A Primer of Enzyme Nomenclature Chapter 14 Rates of Enzymatic Reactions1. Chemical Kinetics2. Enzyme Kinetics3. Inhibition4. Effects of pH5. Bisubstrate ReactionsAppendix: Derivations of Michaelis–Menten Equation Variants Chapter 15 Enzymatic Catalysis1. Catalytic Mechanisms2. Lysozyme3. Serine Proteases4. Drug Design Part IV MetabolismChapter 16 Introduction to Metabolism1. Metabolic Pathways2. Organic Reaction Mechanisms3. Experimental Approaches to the Study of Metabolism4. Thermodynamics of Phosphate Compounds5. Oxidation–Reduction Reaction6. Thermodynamics of Life Chapter 17 Glycolysis1. The Glycolytic Pathway2. The Reactions of Glycolysis3. Fermentation: The Anaerobic Fate of Pyruvate4. Metabolic Regulation and Control5. Metabolism of Hexoses Other than Glucose Chapter 18 Glycogen Metabolism1. Glycogen Breakdown2. Glycogen Synthesis3. Control of Glycogen Metabolism4. Glycogen Storage Diseases Chapter 19 Signal Transduction1. Hormones2. Heterotrimeric G Proteins3. Tyrosine Kinase–Based Signaling4. The Phosphoinositide Cascade Chapter 20 Transport through Membranes1. Thermodynamics of Transport2. Kinetics and Mechanisms of Transport3. ATP-Driven Active Transport4. Ion Gradient–Driven Active Transport5. Neurotransmission Chapter 21 Citric Acid Cycle1. Cycle Overview2. Metabolic Sources of Acetyl-Coenzyme A3. Enzymes of the Citric Acid Cycle4. Regulation of the Citric Acid Cycle5. The Amphibolic Nature of the Citric Acid Cycle Chapter 22 Electron Transport and Oxidative Phosphorylation1. The Mitochondrion2. Electron Transport3. Oxidative Phosphorylation4. Control of ATP Production Chapter 23 Other Pathways of Carbohydrate Metabolism1. Gluconeogenesis2. The Glyoxylate Cycle3. Biosynthesis of Oligosaccharides and Glycoproteins4. The Pentose Phosphate Pathway Chapter 24 Photosynthesis1. Chloroplasts2. Light Reactions3. Dark Reactions Chapter 25 Lipid Metabolism1. Lipid Digestion, Absorption, and Transport2. Fatty Acid Oxidation3. Ketone Bodies4. Fatty Acid Biosynthesis5. Regulation of Fatty Acid Metabolism6. Cholesterol Metabolism7. Eicosanoid Metabolism: Prostaglandins, Prostacyclins, Thromboxanes, Leukotrienes, and Lipoxins8. Phospholipid and Glycolipid Metabolism Chapter 26 Amino Acid Metabolism1. Amino Acid Deamination2. The Urea Cycle3. Metabolic Breakdown of Individual Amino Acids4. Amino Acids as Biosynthetic Precursors5. Amino Acid Biosynthesis6. Nitrogen Fixation Chapter 27 Energy Metabolism: Integration and Organ Specialization1. Major Pathways and Strategies of Energy Metabolism: A Summary2. Organ Specialization3. Metabolic Homeostasis: Regulation of Appetite, Energy Expenditure, and Body Weight4. Metabolic Adaptation Chapter 28 Nucleotide Metabolism1. Synthesis of Purine Ribonucleotides2. Synthesis of Pyrimidine Ribonucleotides3. Formation of Deoxyribonucleotides4. Nucleotide Degradation5. Biosynthesis of Nucleotide Coenzymes Part V Expression and Transmission of Genetic InformationChapter 29 Nucleic Acid Structures1. Double Helical Structures2. Forces Stabilizing Nucleic Acid Structures3. Supercoiled DNA Chapter 30 DNA Replication, Repair, and Recombination1. DNA Replication: An Overview2. Enzymes of Replication3. Prokaryotic Replication4. Eukaryotic Replication5. Repair of DNA6. Recombination and Mobile Genetic Elements7. DNA Methylation and Trinucleotide Repeat Expansions Chapter 31 Transcription1. The Role of RNA in Protein Synthesis2. RNA Polymerase3. Control of Transcription in Prokaryotes4. Post-Transcriptional Processing Chapter 32 Translation1. The Genetic Code2. Transfer RNA and Its Aminoacylation3. Ribosomes4. Control of Eukaryotic Translation5. Post-Translational Modification6. Protein Degradation Chapter 33 Viruses: Paradigms for Cellular Function W-11. Tobacco Mosaic Virus W-32. Icosahedral Viruses W-83. Bacteriophage W-204. Influenza Virus W-40 Chapter 34 Eukaryotic Gene Expression1. Chromosome Structure W-532. Genomic Organization W-683. Control of Expression W-834. Cell Differentiation W-121 Chapter 35 Molecular Physiology1. Blood Clotting W-1652. Immunity W-1793. Motility: Muscles, Vesicle Transport, Cilia, and Flagella W-211 Index I-1 and WI-1