Description
RSC Phage Nanobiotechnology 2011 Edition by Valery Petrenko
Several books and many papers have been published during the last decade on the design and the use of new nanomaterials in medicine and technology, which describe major concepts of nanotechnology. Meanwhile, a new promising type of nanomaterials-bacteriophages-emerged recently as a result of the evolution of phage display technique. Bacteriophages have a unique feature - completely the opposite of other nanomaterials -their structure and function are encrypted in their genomic DNA, which can be intentionally modified or even rewritten using routine genetic engineering techniques. In particular, a paradigm of landscape phage with multivalently displayed foreign peptides evolved, which allows constructing phage with unique surface architectures and emerged properties. Recently, phage, as a new kind of nanomaterials attracted the attention of specialists working in peripheral, and even very diverse areas from genetics and molecular biology, such as pharmaceutical science, material science, microelectronics, biosensors, detection, environmental sciences, etc. Penetration of the phage technology into these new disciplines required the development of a new instructive concept, which resulted in this publication. This comprehensive book, of value to researchers as well as scientists, introduces readers into this hot new area of phage nanobiotechnology. It summarises the existing data on the phage nanomaterials and discusses their use in different areas of medicine, science and technology. With contributions by top level experts and pioneers in phage display, the major goal of this book is to bring the phage display technique closer to specialists in these diverse areas of medicine, science and technology, where phage-derived nanomaterials can be most beneficial. Structure of Filamentous Phage Particles and Their Components; Amplification and Self Assemblage of Phage Particles; Evolution of Phage Display towards Nanotechnology; Imaging with Phage Derived Probes; Phage-Derived Vectors for Gene Delivery; Phage-Mediated Drug Delivery; Phage Immunogens and Vaccines; Phage-Templated Synthesis of Inorganic Nanomaterials; Phage-based Biorecognition Interfaces in Biosensors; Reporting phage for detection of biological threats; Site-Directed Chemical Modification of Phage Particles; Combinatorial Phage Nanobiotechnology