Optimization In Drug Discovery : In Vitro Methods at Meripustak

Optimization In Drug Discovery : In Vitro Methods

Books from same Author: Caldwell

Books from same Publisher: Springer

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  • General Information  
    Author(s)Caldwell
    PublisherSpringer
    Edition2
    ISBN9781627037419
    Pages580
    BindingHard Bound
    LanguageEnglish
    Publish YearJanuary 2013

    Description

    Springer Optimization In Drug Discovery : In Vitro Methods by Caldwell

    Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.