Description
Piccin Hemoglobinopathies From Diagnosis To Specialized Consultancy (Hb 2022) by Barberio G
This book summarizes the results obtained by capillary electrophoresis (CE) using Capillarys 3 (Sebia) during phenotype studies of the different hemoglobin (Hb) disorders. Historically, studies of Hbs by liquid electrophoresis started in 1949 with Pauling revealing that the mobility of Hb S differed from that of Hb A. At this time only a very limited number of electrophoresis equipment, U-tubes type, was available and several hours were required to perform each analysis, a special optical device (Schlieren) was necessary to follow the electrophoretic separation of the Hb components and no quantitative measure was possible. This was only, and hardly, an analytical method.