Description
John Wiley Haematology From The Image To The Diagnosis by Mike Leach, Barbara J. Bain
Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis. Using a novel format of visual case studies, this text mimics 'real life' for the practising diagnostic haematologist - using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct?descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work. Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike. PrefaceAbbreviations1. Haemophagocytic syndrome secondary to anaplastic large cell lymphoma2. Bone marrow AL amyloidosis3. Cup-like blast morphology in acute myeloid leukaemia4. Neutrophil morphology5. Primary myelofibrosis6. Sarcoidosis7. Leishmaniasis8. Gelatinous transformation of the bone marrow9. Acanthocytic red cell disorders10. Large granular lymphocytic leukaemia11. Pure erythroid leukaemia12. Reactive mesothelial cells13. Plasmablastic myeloma14. Septicaemia15. Unstable haemoglobin (haemoglobin Koeln) and a myeloproliferative neoplasm16. Sickle cell anaemia in crisis17. Acute myeloid leukaemia with t(8;21)(q22;q22.1)18. Chronic neutrophilic leukaemia19. Essential thrombocythaemia20. Hairy cell leukaemia21. Mantle cell lymphoma in leukaemic phase22. Infantile osteopetrosis23. Reactive eosinophilia24. Stomatocytic red cell disorders25. Reactive lymphocytosis due to viral infection26. Therapy-related acute myeloid leukaemia with eosinophilia27. Red cell fragmentation syndromes28. NK/T-cell lymphoma in leukaemic phase29. Myelodysplastic syndrome with del(5q)30. Classical Hodgkin lymphoma31. Cryoglobulinaemia32. Congenital dyserythropoietic anaemia33. Acute monoblastic leukaemia with t(9;11)(p21.3;q23.3)34. Chronic myeloid leukaemia presenting with myeloid sarcoma and extreme thrombocytosis35. Glucose-6-phosphate dehydrogenase deficiency36. Leukaemic presentation of hepatosplenic gamma-delta T-cell lymphoma37. Myelodysplastic syndromes38. Pelger-Huet anomaly39. Russell bodies in lymphoplasmacytic lymphoma40. T-cell prolymphocytic leukaemia41. Myeloid maturation arrest42. MDS/MPN with ring sideroblasts and thrombocytosis43. Acute myeloid leukaemia with inv(16)(p13.1q22)44. Babesiosis45. Haemoglobin E disorders46. Juvenile myelomonocytic leukaemia47. Non-haemopoietic tumours48. Richter transformation of chronic lymphocytic leukaemia49. Sickle cell-haemoglobin C disease50. T cell/histiocyte-rich B-cell lymphoma51. Miliary tuberculosis52. Pure red cell aplasia53. Lymphoblastic transformation of follicular lymphoma54. Primary hyperparathyroidism55. Gamma heavy chain disease56. Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.2)57. AA amyloidosis58. Acquired sideroblastic anaemia59. Diffuse large B-cell lymphoma60. Hickman line infection61. Monocytes and their precursors62. Paroxysmal cold haemoglobinuria63. Transient abnormal myelopoiesis64. Systemic lupus erythematosus65. Granular blast cells in acute lymphoblastic leukaemia66. Chronic myelomonocytic leukaemia67. Burkitt lymphoma/leukaemia68. Gaucher's disease69. Myelodysplastic syndrome with haemophagocytosis70. Primary oxalosis71. Acute myeloid leukaemia with inv(3)(q21.3q26.2)72. Autoimmune haemolytic anaemia73. Chronic eosinophilic leukaemia due to FIP1L1-PDGFRA fusion gene74. Leukaemic phase of follicular lymphoma75. Megaloblastic anaemia76. Reactive bone marrow and an abnormal PET scan77. Acute megakaryoblastic leukaemia78. Erythrophagocytosis and haemophagocytosis79. Hyposplenism80. Acquired haemoglobin H disease81. Cystinosis82. Familial platelet disorder with a predisposition to AML83. Nodular lymphocyte predominant Hodgkin lymphoma84. Acute monocytic leukaemia with NPM1 mutation85. Adult T-cell leukaemia/lymphoma86. Hereditary elliptocytosis and pyropoikilocytosis87. Sezary syndrome88. Spherocytic red cell disorders89. Acute myeloid leukaemia and metastatic carcinoma90. Chediak-Higashi syndrome91. Cortical T-lymphoblastic leukaemia/lymphoma92. Trypanosomiasis93. Acute myeloid leukaemia with myelodysplasia-related changes94. Blastic plasmacytoid dendritic cell neoplasm95. Inherited macrothrombocytopenias96. Persistent polyclonal B-cell lymphocytosis97. Acute myeloid leukaemia with t(6;9)(p23;q34.1)98. B-cell prolymphocytic leukaemia99. Various red cell enzyme disorders100. Sea blue histiocytosis in multiple myeloma101. Enteropathy-associated T-cell lymphomaAnswers to multiple choice questions and further reflections on the themeIndex