Embryo Implantation

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Springer Embryo Implantation by Carson Daniel D. (Ed.)

Embryoimplantationisaremarkableandcomplexprocess. Approachesde- VelopedfromthefieldsofcellanddevelopmentalbiologyImmunology Andmolecularbiologyhavegreatlyenhancedourabilitytostudythe Sharedaswellasuniquefeaturesofembryo-Uterineinteractions. Impres- Siveandcriticalgroundworkhasbeenlaidbyalargeanddedicatedarray OfendocrinologistsReproductivebiologistsAndanatomists. Thesestudies Havesetthestagetoutilizesensitiveandsophisticatedtechniquestode- Tectandmodulateproteinandgeneexpression. Justasthesymbiosisofmother AndfetusiscriticalforthemaintenanceofpregnancySoisthesynergyamong InvestigatorsfrommanydisciplinesBothinbasicandclinicalarenasKeyto Unravelingthemysteriesofimplantationandplacentation. Alargegroupof Contributorsinthisfieldhadtheopportunitytomeetanddiscussthestateof ThisartwiththesupportofseronosymposiausaInc. Whileitisneverpos- SibletobringtogethereveryonewhohasplayedanimportantroleItwas NonethelessBothexcitingandgratifyingtohavesomanycolleaguestogether Forthisevent. InthechaptersthatfollowThehighlightsofthismeetingarepresented Assummarizedbytheindividualpresentersofsevendifferentsessions.The Topichasbeenconsideredfromthebroadsocialandethicalimplications Ofmoderninvitrofertilizationandassistedreproductivetechnologiesto Detailedmolecularcontrolsovereventsthatoccurduringembryonicdevel- OpmentUterinepreparationforimplantationAndplacentalorganogenesis. Thesechaptersdemonstratethesignificantandrapidprogressbeingmade Inthisfieldofbiologyandmedicine. AtthesametimeTheyshowthat Muchmoreneedstobedonetounderstandandfullyappreciatethispro- Cess. Lessonslearnedfromthiseffortcanbeexpectedtocontinuetopro- VideinsightsintootherRelatedfields. Ofthemanycontributorstoour UnderstandingoftheprocessofimplantationNonehavehadalargerim- PactthanourcolleagueAllenenders. Dr. Endershasplayedaparamount Roleindevelopingthebasicunderstandingofthecellbiologicalprocesses Vii Viii Preface UnderlyingimplantationandplacentationinmanyspeciesIncludinghu- Mans. Hecontinuestocontributeandguidethoughtintheseareas. The Participantsofthissymposiumrecognizeddr. EndersImpressivecontribu- Tionsbyholdingthiseventinhishonor. Danield. Carson * Contents Preface Vii Contributors Xiii Parti. Development And Future Ofhuman In Vitro Fertilization And Embryo Implantation I.Implantationinthehumanasviewedbycanonlaw CivillawAndnaturalreason 3 Howardw. Jones Jr. Richarda. Mccormick And Susan L. Crockin 2. Theimpactofmaternalageandovarianage Onimplantationefficiency...12 Steven Spandorfer And Zev Rosenwaks Part Ii. Cellularaspects Ofimplantation 3. Vascularinvasionduringimplantationandplacentation 23 Allen C. Enders And Thomasn. Blankenship 4. Oxygenregulateshumancytotrophoblastproliferation DifferentiationAndinvasion:Implicationsfor Endovascularinvasioninnormalpregnancy Andpreeclampsia 39 Olga GenbacevYan Zhou Michael T. Mcmaster Johnw. Ludlow Carolineh. Damsky And Susan1. Fisher 5. Embryo-Maternalinteractionsafterdiapause Inamarsupial 54 Marilynb. Renfree And Geoffrey Shaw Ix X Contents 6. Cellularinteractionsandthecysteineproteinases Intheprocessofmouseimplantation 67 Bruce Babiarz Suzanne Afonso Andlinda Romagnano Part Iii. Hormonalregulation 7. Novelsteroid-Regulatedmarkersofimplantation 83 Indranic. Bagchi 8. Molecularsignalinginimplantation 92 Sanjoyk. Das Bibhashc. Paria And Sudhansu K. Dey 9. Identificationofprogesterone-Regulatedgenes Intheuterus 107 Cindeer. Funk Bertw. OMalley And Francesco1. Demayo Partiv.Molecularmarkersofreceptivity 10. Mucinsprovideabarriertoembryoimplantation 123 Marym. Desouza Gulnara. Surveyor Xinhui Zhou Joanne Julian Anddanield. Carson Ii. PotentialinvolvementoftrophininBystin Andtastininembryoimplantation 132 Michikon. Fukuda Daita NadanoNao Suzukj And Jun Nakayama 12. Osteopontininhumanendometrium: Aroleinendometrialreceptivityand Embryoimplantation? 141 Christos CoutifarjsAkinyinka Omigbodun Piotr Ziolkiewicz And John Hoyer Partv. Trophoblastfactors 13. Therabbitasamodelforimplantation: Invivoandinvitrostudies 151 Lorenh. HoffmanD. Rachel Breinan And Garethl. Blaeuer 14. Regulationoftrophoblastendocrinefunction: Theplacentadoesitsownthingtranscriptionally...161 Jeromef. Straussiii Andlee-Chuankao Contents Xi 15. Transcriptionfactorsregulatingthedifferentiation Ofthetrophoblastcelllineage 167 Ianc. Scottandjamesc.Show More