Dna Conjugates And Sensors at Meripustak

Dna Conjugates And Sensors

Books from same Author: Keith R Fox and Tom Brown

Books from same Publisher: Royal Society Of Chemistry

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  • General Information  
    Author(s)Keith R Fox and Tom Brown
    PublisherRoyal Society Of Chemistry
    ISBN9781849734271
    Pages316
    BindingHardback
    LanguageEnglish
    Publish YearOctober 2012

    Description

    Royal Society Of Chemistry Dna Conjugates And Sensors by Keith R Fox and Tom Brown

    Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book is relevant to researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.